A primer on combined Fibroblast and Adipose Stem Cell Conditioned Media as a skincare ingredient.
Quick question for our BFT readers, especially those who have been keeping up with our series on cell culture derived bio-signals in skincare:
What would prompt a company to launch a product line combining the weak bio-signals produced by fibroblasts in culture with the highly pro-inflammatory ones produced by adipose (fat) derived stem cells?
That seems illogical to BFT and the literature – some of it recent – confirms that this is a bad idea.
For the record, BFT has no quarrel with anyone taking advantage of a legitimate and legal opportunity to make money. That’s the American Dream. Your humble hosts, Drjohn and Drgeorge, have been busy these past few years doing the very same thing.
From day one, however, one of our missions has been to empower our readers with the knowledge necessary to make informed choices about how they invest their skincare dollars.
There are a number of cell culture-based products available. Before you open your wallet to buy products containing combined fibroblast and adipose derived stem cell conditioned media, you should take a few minutes to arm yourself with the science required to make an informed decision on whether or not this kind of product is for you.
A NEW GROWTH FACTOR “STORY”: MULTIPLE CELL TYPE CULTURES
The April 2014 issue of The Journal of Drugs in Dermatology made it clear that dermatologists are lining up in agreement that topical bio-signals play an important role in skincare. In a feature article, Cytokines and Growth Factors were placed at the top of the Skin Health and Beauty Pyramid – above retinoids, above alpha hydroxyl acids, above sun blocks, above everything.
This is the major reason that new growth factor and cytokine products have multiplied in number over the past couple years.
Often, their stories lack important significant details about the underlying science. We feel this is one of those instances.
NEW MEANS BETTER? DON’T BELIEVE IT.
While “better” can be crafted into seductive-sounding prose that entices the non-scientist consumer to buy, BFT advises caution. The science of a fibroblast / fat stem cell culture combination doesn’t confirm better, it confirms lack of understanding of the basic physiology of tissue healing and the negative role inflammation can and does play in that process.
Why would anyone want to apply daily skincare products that promote inflammation when it has been known for decades that inflammation actually promotes tissue aging? And what about the very well-known relationship between inflammation and the promotion of fibrosis (scarring) and hyperpigmentation?
That’s a question we continue to ask, perhaps into the cone of silence, since no one has yet given us an answer.
And, fibroblasts? The bio-signals produced by them are so paltry that the first-generation product produced using fibroblast conditioned media contains more than 93% conditioned media, which because of the protein content gives TNS an odor that some people are not fond of. Smelly gym locker, anyone?
And if it takes that amount to get any oomph, there is no room in the formulation to add other recommended actives; that means buying numerous products and maintaining a complicated skincare routine.
Let’s get to specifics.
Fibroblasts are nice enough cells and because our bodies contain enormous amounts of connective tissue, they are the second most abundant cell in the body, surpassed only by red blood cells. The job of fibroblasts is to produce collagen, elastin, reticular fibers and matrix. When it comes to producing bio-signals, they’re weaklings; when it comes to providing structure and strength to tissues and organs, they’re bodybuilders supreme.
Compared to the stem cell we champion, the bone marrow mesenchymal stem cell, fibroblasts are very puny, indeed. The images below show the comparative output of important biosignals by fibroblasts and bone marrow mesenchymal stem cells. In the graph, the small white bars indicate 1X of these biosignals, the amount produced by fibroblasts in culture. Below that is a chart that indicates how many fold increase is produced by bone marrow mesenchymal stem cells in culture.
But that’s only part of the story. Several of the bio-signals produced by fibroblasts are pro-inflammatory e.g. TGFb1, IL-1b, IL-6, IL-33.
Furthermore, fibroblasts don’t give orders, they take them. Their orders come from the migratory bone marrow mesenchymal stem cells that patrol our tissues via the vasculature. These cells arrive at sites of injury and produce the bio-signals that instruct neighboring cells, including fibroblasts, what to do and when to do it. In skin physiology and healing, fibroblasts are following orders, not giving them.
The two articles below cover this is some detail. Rodent wound models shows significant healing with bone marrow stem cell conditioned media applied; fibroblast conditioned media did no better than media is which no cells whatsoever were grown. Puny producers of biosignals. Puny, indeed.
Mesenchymal stem cells induce dermal fibroblast responses to injury Experimental Cell Research Volume 316, Issue 1, 1 January 2010, Pages 48-54
Fibroblasts in fibrosis: novel roles and mediators Front Parmacol. 2014;5;123
ADIPOSE (FAT) DERIVED STEM CELLS
Fat has long been recognized as an endocrine organ, secreting a variety of bio-signals that can have negative physiologic consequences. As the amount of body fat increases, the negative effects are compounded.
The quote below is from an article entitled: Biochemistry of adipose tissue: an endocrine organ Arch Med Sci. 2013 Apr 20; 9(2): 191–200.
“[….]As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormones. These are active in a range of processes, such as control of nutritional intake (leptin, angiotensin), control of sensitivity to insulin and inflammatory process mediators (tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), resistin, visfatin, adiponectin, among others) and pathways (plasminogen activator inhibitor 1 (PAI-1) and acylation stimulating protein (ASP) for example).”
The biologic effects of these bio-signals are numerous, as demonstrated in the accompanying diagram.
Not surprisingly, adipose (fat) derived stem cells also have a highly pro-inflammatory cytokine profile. Hence, these are the bio-signals contained within the conditioned media when fat stem cells are cultured in the laboratory. The balance beam graphic is highly pro-inflammatory.
What does that mean for products that contain fat stem cell conditioned media? It means that the net biologic effect on the skin will be to promote inflammation, and daily use will produce a chronic inflammatory stimulus which is not anti-aging at all, but the exact opposite. Not a good idea.
HOW INFLAMMATORY STIMULATION CAN PRODUCE POSITIVE CHANGES IN SKIN APPEARANCE – FOR A WHILE.
Inflammation can be “clinical”, with all of the manifestations seen in this injured finger example. We are all familiar with that phenomenon. Inflammation can also be “subclinical”, meaning that despite the fact that some of the classic signs are not evident, inflammation is present nonetheless. Chronic smoldering internal inflammation is present in many diseases and conditions of advanced age, most notably diabetes and atherosclerosis.
You can see from the finger example above that one of the hallmarks of inflammation is edema, or swelling, called tumor in Latin. It is BFT’s strongly held conviction that the edema that is present, even with subclinical inflammation, is what gives the appearance of smoother, plumper skin with many products – the edema associated with inflammation can make fine lines disappear, for a while.
It is well proven that inflammation is pro-aging in all tissues. It is also well proved that inflammation contributes to fibrotic healing (scarring) and melanocyte stimulation, the reason that darker skin types are susceptible to post-inflammatory hyperpigmentation after any kind of injury to the skin. Does chronic subclinical inflammation of the skin sound like something desirable as an anti-aging strategy?
Not to us. Therefore the decision to produce a combination product containing conditioned media from fibroblasts and adipose derived stem cells is perplexing and irrational.
BEWARE WHAT STORIES YOU BELIEVE.
But, hey, no one ever said that skincare products have to make scientific sense; they just have to have a story that can be massaged into a marketing meme that can be parlayed into cash flow.
Perfect examples are plant “stem cell” products which have been around for years. To the unwary, it’s easy to pass off as plausible any number of stories. Here’s just three:
• A type of Swiss apple, grown preferentially during the 1800’s because of its ability to be cellared for long periods of time without shriveling and rotting, makes it the perfect stem cell “source” to help prevent and treat wrinkles in human skin.
• The Alpine edelweiss, which grows at high altitudes and thrives while being bombarded with increased UV exposure from the sun, is the perfect stem cell “source” for products that prevent and help repair the skin damage of sun exposure.
• Because date palms thrive in very arid and hot climates, they are the perfect “source” for stem cells that can help protect the skin from the effects of arid and hot conditions.
A bit of scientific reflection is all that is required to debunk these sales pitches as nonsense, but such products sell.
Now, admittedly, we are not talking such craziness here, fibroblast and fat stem cell culture-derived products have a much more plausible marketing story. In fact, “two-for-one” alone may entice purchasers to give it a try. But, just as two wrongs don’t make a right, two non-suitable cell types don’t make a superior skincare product.
It’s the details of the kinds of human bio-signals produced in culture that are important. Know and understand the details.
WHERE DO THE FIBROBLASTS AND FAT STEM CELLS COME FROM?
Were it not for their use in cell culture, the tissues sources for fibroblasts and fat stem cells would be incinerated as medical waste. Fibroblasts are typically sourced from the discarded foreskins of circumcised male infants, and fat stem cells from the fat removed from middle-age women during liposuction. Fibroblasts and fat stem cells are therefore plentiful, easy to obtain and inexpensive.
INTERESTING COMPARISONS OF FAT STEM CELLS TO BONE MARROW STEM CELLS
Stem cells have been investigated in medical research and practice for well over two decades. Recently the global number of research articles that examined the basic physiology, characteristics and clinical used of stem cells surpassed 300,000! All types and sources of stem cells have been studied, with nearly 2/3 of them focusing on bone marrow stem cells which have proved superior to all other types in many ways. One major use of stem cells in clinical practice has been in orthopedics to aid in regeneration and treatment of cartilage disorders. The graph below shows that bone marrow stem cells have received the greatest scrutiny.
Of particular interest is the fact that adipose stem cells are so much more plentiful and easier to obtain, yet bone marrow stem cells continue to be the “go to” cell in regenerative and therapeutic medical applications. This should not be surprising since this is their physiologic role throughout life – repair and regeneration of damaged tissue. The physiologic role of fat stem cells? Make more fat; nothing more.
Despite being relatively much less plentiful within their tissue “niche”, which makes them more difficult to obtain, bone marrow stem cells continue to be the preferred stem cell type for medical research and therapies.
ADDITIONAL THINGS TO PONDER ABOUT FAT STEM CELLS
Procoagulant activity of human mesenchymal stem cells
J Trauma Acute Care Surg. 2017 Jul;83(1 Suppl 1):S164-S169.
[…..] All MSC populations are not equivalent; care should be taken to select cells for clinical use that minimize potential safety problems and maximize chance of patient benefit. Adipose-derived MSCs seem more consistently pro-coagulant than BM-MSCs, presenting a potential safety concern…
A Proinflammatory Secretome Mediates the Impaired Immunopotency of Human Mesenchymal Stromal Cells in Elderly Patients with Atherosclerosis Stem Cells Translational Medicine 2017.6:1132-1140
[…..] Elderly adipose MSCs exhibited a pro-inflammatory secretome with increased levels of IL-6, IL-8, CXCL8, and MCP-1/CCL2. (BFT note: the summary is that the older the source of the fat stem cell, the more inflammatory will be its secreted biosignals. Fat stem cells in skin products are sourced from liposuction waste. The average liposuction patient in the U.S. is an overweight female in her early fifties.)
Review Article: Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering. Stem Cells International, Vol 2016, article ID 3206807
[…..] ADSCs may exert unintended paracrine and endocrine effects on peripheral tissues (through) secretion of metabolically active hormones such as leptin and cytokines such as TNF-a and IL-6…Obese derived ADSCs induce a pro-inflammatory response… (BFT note: patients undergoing liposuction, the source of ADSCs commercially, are not lean but significantly overweight.)
Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived but Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem Cells 2015 Sep;33(9):2773-84
BM-MSCs and ASCs cultured under identical osteogenic (bone forming) conditions responded differently with ASCs producing more calcium per cell.
Comparison of autologous bone marrow and adipose tissue derived mesenchymal stem cells, and platelet rich plasma, for treating surgically induced lesions of the equine superficial digital flexor tendon. Vet J. 2017 Jun;224:76-84.
[…..] BM-MSCs resulted in a better outcome than PRP and AT-MSCs.
I’m using Skinceuticals C E Ferulic. Do I still need to use it if I start using AnteAge Serum? Being a male I try to use fewer products to avoid a shiny face, etc. I also use Obagi tretinoin o.1%. I would like to hear your opinion.THANKS
The Skinceutical product, C E Ferulic, contains antioxidants, important in preventing damage from free radicals (reactive oxygen species) that occur from solar radiation, inflammation from any source, even the oxidation of fuel (food) within our cells mitochondria. The Obagi product contains low concentration of retinoic acid. The AnteAGE system contains a variety of antioxidants (C, E, botanicals such as Yerbe Mate) so you will no longer need C E Ferulic. It also contains retinol in the Accelerator, a molecule that an enzyme within the skin converts to retinoic acid, so you would not need the Obagi product either.
The Accelerator contains ceramides and lipids which restore barrier function and improve skin moisturization. People who find it too “rich” for their skin sometimes use the Serum during the day and Serum / Accelerator at night. If you do decide to try our products, let us know how your skin improves – it will.
Thank you for this article! It breaks the issue down in an extremely comprehensible way. I’ve been trying to explain to my mother why her adipose stem cell treatment for her osteoarthritis didn’t work and now I’ve got the simple words to do that.
And thank you for developing AnteAge products, which I guess I’ve been using for around two years now. I recently went for an Excel V treatment and the doctor kept exclaiming how great my 55 year old skin looked. I’m happy.
To be clear, the issue of using fat stem cells for orthopedic injections for various “arthritis” issues is somewhat different from our concerns regarding topical application to the skin. Whereas initiating inflammation in the skin, especially for the purposes of addressing the issues that occur with aging, is counterproductive, there are instances where the injection of fat stem cells may indeed have benefit. It depends on what the orthopedic issue is. That said, the vast majority of research dealing with stem cells for tissue repair and rejuvenation utilizes bone marrow mesenchymal stem cells. Makes sense, right? Bone marrow stem cells are the cells tasked with tissue repair and rejuvenation throughout our lifespan.
Orthopedic injection of fat stem cells usually comes with the proviso: “Well. let’s give it a try and see if it helps.” Sometimes it does, and sometimes surgery including joint replacement is required to resolve symptoms. (Drgeorge should know; he just had bilateral total hip replacements a few months ago and feels 20 years younger!!)
Thank you for using AnteAGE products. You confirm our motto coined many years ago – “Women don’t like AnteAGE, they LOVE it!”
I am one who LOVES the AnteAgeMD line because it does very good things. A quick question. Have you heard of Alphaeon Growth Serum? Contains synthetic GFs claiming to be anti-inflammatory and more stable that human derived. A client of mine swears she hasn’t needed botox since using (GFs wouldnt do that on a 50+ year old in mere months).
Another example of marketing that needs close scrutiny. Everyone is jumping on the topical growth factor bandwagon and we can’t be critical of the concept since that is the sandbox we play in. But people, be wary. The science sometimes makes perfect physiologic sense, and sometimes it stinks. This one doesn’t smell so good.
We have long cautioned against products with single growth factors, particularly EGF. Read the post on BFT about EGF by Drjohn that goes into the subject in detail. The body doesn’t work this way – there are ALWAYS many bio-signals in play – elaborate symphonic harmonies, not single note boredom. Furthermore, the EGF in the Alphaeon product we saw on their website is hardly anti-inflammatory. Just take a look at the references that popped up with a simple Google search:
Review Article – IL-1 and EGF regulate expression of genes important in inflammation and cancer Cytokine Volume 62, Issue 1, April 2013, Pages 22-33
The epidermal growth factor receptor: a link between inflammation and liver cancer. Exp Biol Med (Maywood). 2009 Jul;234(7):713-25.
Research Article – The Epidermal Growth Factor Receptor Increases Cytokine Production and Cutaneous Inflammation in Response to Ultraviolet Irradiation Dermatology
Volume 2013 (2013)
We’re very skeptical of the scientific rigor that goes into the professional vetting of products at Alphaeon. They were signed on to market the product BFT has written about that was based on CSC14 cells, now exposed and revealed as human embryonic stem cells. Nowhere in any marketing material was that fact made clear to unsuspecting consumers, many of whom we are sure would have ethical concerns about slathering products on their face based on human embryos. There is real science in this field. It should not just be about pitching the next “great thing” to a scientifically naive populace.
Thx DrG. In terms of synthetic vs human derived, can you share further your thoughts on that please.
Your question is very apropos since some parts of the world, most notably the European Union, do not permit marketing of human cell-derived products. The prohibition goes back decades to the time of the European (primarily British) “mad cow” disease panic of the 80s and 90s. A little bit about bovine spongiform encephalopathy (“BSE”) in a moment. First, let’s look at synthetic cytokines and growth factors.
Many bio-signals have been studied in depth, to the point of knowing their molecular structure precisely, as well as the genetic code responsible for their production. With this knowledge, it is possible to transfect, i.e. insert genetic code, into bacteria, yeast, fungi, insects, animal and plant cells, making these non-human cells capable of producing exact molecular copies of human bio-signals. This process is referred to “recombinant” synthesis. It is also possible to chemically “assemble” exact replicas of the molecule.
The physiologic effect of most bio-signals has been studied to the point that their effects on human cells can be accurately predicted. As we have discussed elsewhere in BFT, nowhere in human physiology does a bio-signal (cytokine, growth factor, interleukin, interferon, etc.) function in isolation, but rather in combination with many other bio-signals simultaneously present. The physiologic result is their net stimulatory and inhibitory effect. For this reason, we are not advocates of skincare products that tout the use of only one or two synthetic bio-signals.
Our opinion is synthetic bio-signals should be used in logical and rational combinations that more closely mimic how our bodies function. We have, in fact, developed a product platform based on this technology for markets where human cell derived bio-signals are not permitted. Products based on this platform may contain eight or more bio-signals, the selection of which is based on the knowledge and experience we have garnered through our work with bone marrow mesenchymal stem cells.
In 1996, the EU banned use of human derived tissues or products in skincare. Their concern was, and continues to be, disease transmission despite the fact that searches done now of PubMed (international internet based medical and scientific search engine), Google Scholar and the FDA database fail to produce a single instance of disease transmission in this way. It is well established that prion diseases – bovine spongiform encephalopathy and human spongiform encephalopathy aka Creutzfelt-Jacob disease – are never transmitted by casual contact or topical application of products to the skin. The means of transmission are 1) genetic inheritance; 2) ingestion of infected tissue, specifically cattle brain or spinal cord; 3) tissue or organ transplantation, with four cases related to blood transfusion.
Nonetheless, the “panic” in Europe was well justified. Data shows during the 1980s and 1990s, there were 188,652 confirmed cases of BSE worldwide, with 183,841 of these infected cattle in Great Britain. 229 people contracted a human variant of BSE through ingestion of infected cattle brain or nervous tissue, 176 of them in Great Britain. In 2008, only two patients contracted the disease, both in Great Britain.
The ban on human cell culture derived products is related to the use of fetal bovine serum (FBS) during the cell culture process. FBS is obtained through sterile exsanguination of fetal calves during the slaughter process of pregnant cows. Cell culture techniques have been developed that do not require the use of FBS. To BFT’s knowledge, there is no record of SBE having been transmitted by FBS.
Do you know any practitioners in NY that are using Procell therapies? I’d like to do a treatment using the full kit ( the micro channeling device etc)
All the best,
We suggest you contact ProCell Therapies through their website. They should have all the information you need. They have wonderful products!
Hey Docs, hope you are well. Still n love with my AnyteAgeMD stem cytokines! Have you any thoughts on neogenisis? A lot of Estheticians are in WOW with their stem cell (human derived from skin cells?) and more recently a mask that pro ports to mimic the effects of Collagen modeling fillers (called Sculplla?) by infusing dissolvable suture material into the skin where is holds things firm for upto 5 months at a time. Used with their stem cell mists and serums, some Esthys claim to be seeing miracles. Pushing aside the hype, wondering what you thought of the quality of their stem cells?
I am interested in your product. I have several topical allergies including Candelilla so I can use your serum but not your accelerator. I currently use Avene Xeracalm Balm but it has not helped heal the skin damage, dryness and aging that was caused from using the strongest LED Red light device on the OTC market. I used to look younger than my age and the LED Red light use over about a month (almost 4 years ago) caused severe dryness, loss of cushion and bounce, sagging, jowls, redness, and sensitivity to just about everything. My skin is paper thin, wrinkly, yellowed, dry and painful. I was also using Bionect HA to try to help moisturize/heal the skin. I would like to try your serum but I need to use a cream to keep this stiff dry, painful skin pliable and hydrated. Any ideas on a cream that can hydrate the skin with the proper ceramides and lipids?
Thanks for your interest in our product. Have you tried the Accelerator on your skin at all? I suggest the inner arm or somewhere inconspicuous to see if you indeed have a reaction. We realize some people may have issues with one ingredient or another, some of this may be dose related and affect some people but not others. We are in the late stages of creating an Accelerator for sensitive skin so visit anteage.com occasionally and you’ll see it when it launches. Most people find our Accelerator an extremely effective moisturizer. If you do have a reaction to our product, I suggest you do some google searches to find products with the ingredients you are seeking. Let us know how it goes.
I guess that was your review of Keracell 🙂
And all others with the same/similar whacky ingredients that ignore real science 🙂
I had major damage from microneedling and am trying to find something to use to help repair the damage. Someone has suggested I use serrapeptase to break down scar tissue. Do you know anything about this? Also, do you have an opinion on the use of topical curcumin in skin health?
Serrapeptase – also known as serratiopeptidase – is a proteolytic enzyme that breaks proteins down into their constituent amino acids. It is produced by bacteria within the digestive tract of silkworms, allowing the emerging moth to consume and digest its silk cocoon. A 2017 review in the Asian Journal of Pharmacologic Science states: “Serratiopeptidase, a proteolytic enzyme from the trypsin family, possesses tremendous scope in combating inflammation. Serine protease possesses a higher affinity for cyclooxygenase (COX-I and COX-II), a key enzyme associated with the production of different inflammatory mediators including interleukins (IL), prostaglandins (PGs) and thromboxane (TXs) etc.” This does support its use in reducing inflammation and pain.
The use of proteolytic enzymes like trypsin, chymotrypsin, and bromelain came into practice in the 1950s in the United States after their anti-inflammatory effects were observed. A similar effect was noted for serrapeptase in Japan in the late 1960s. It has since been used in a variety of clinical settings including to reduce pain, muscle spasm, inflammation, and edema following wisdom teeth removal. It has also been found beneficial in a study of 200 people with inflammatory ear, nose, and throat conditions. In patients with COPD (chronic obstructive pulmonary disease), airway inflammation was reduced and mucus clearance increased. There are, however, side-effects reported including skin reactions, muscle and joint pain, poor appetite, nausea, stomach pain, cough, and blood clotting disturbances.
The use of serrapeptase has been advocated as a health supplement to prevent cardiovascular morbidity. Existing scientific evidence, however, is insufficient to support its use for these purposes. In fact, there is evidence that use of serrapeptase in some individuals may be inadvisable. A cursory PubMed search found two published cases of elderly Japanese users developing pneumonia and lung injury. Based on what benefits are proven and potentially detrimental effects described, we cannot recommend its use for “scar management” regardless of etiology. That in addition to the mechanism of action being extremely unlikely to provide significant benefit to existing scars. BTW, what damage from microneedling did you experience, and how was the procedure performed? We are advocates of microneedling when done properly and with appropriate topical adjuvants.
There is some evidence of the benefits of curcumin applied to the skin but because it is highly hydrophobic (does not like to mix with water), penetration is an issue unless contained within nanosized liposomes (small lipid membrane “envelopes” containing curcumin.)
I’m very confused. NeoGenesis purports that products that utilize BMSC are potentially unsafe with regard to cell proliferation and cancer. They claim adipose stem cells aren’t pro-inflammatory and are safer/better. Please help me to understand and be reassured that AnteAge is safe.
We have been made aware of Dr. Greg Maguire’s allegations from other readers. Rest assured, his article, published in the Journal of Cosmetic and Aesthetic Dermatology last August, and his YouTube videos are very biased and even caught the eye of internationally renowned stem cell experts. They analyzed his article, including the 230 references he cited and found he made dozens of errors that fell into four categories. They were so serious and egregious, these experts wrote to the journal requesting the Maguire article be retracted. Our opinion is his effort was to damage a competitor (your BFT hosts and their skincare brands) and not to accurately describe the science. He makes many erroneous statements and, unless he is not nearly as learned as he professes, does so in a deliberate effort. There are stringent requirements in scientific publishing about how data is utilized; Maguire appears to have fallen short over and over and over. That’s the opinion of experts who know this material inside and out. Maguire should be ashamed.
Look at our most recent posts and you will get much more detailed information.
A youtube video is out from a scientist from Neogenesis that almost calls out AnteAge by name. He attacks bone marrow stem cells while praising fat stem cells. Now I’m totally confused. Would love to know your response.
You’re not alone. Others brought this to our attention. It turns out this “expert” also published an article in a medical science journal making the same claims. It caught the eye of academic stem cell scientists at a major university who found dozens of scientific errors in the article that fell into four different categories. Scientific misconduct includes improperly using and manipulating data in any way that may mislead, including in any published work. A letter to the editor of the journal was sent by them recommending the article be retracted. An inescapable conclusion is the videos and article are an effort by this NeoGenesis scientist to disparage a competitor and little more, something that raises serious ethical concerns.
We published a post about this on BFT at http://barefacedtruth.com/2020/08/22/part-1-accidental-scientific-dishonesty-no-deliberate-and-shameful/
Another follow up post will follow soon.
The second BFT post addressing what academic stem cell scientists consider “scientific misconduct” on the part of a NeoGenesis scientist can be found at http://barefacedtruth.com/2020/08/27/scientific-misconduct-in-medical-aesthetics-research-part-2/ ; It provides details about the more than sixty erroneous uses of citations and references contained in what we consider to be little more than a “hit piece” against a commercial competitor. The lesson to learn: Don’t believe everything you read in scientific journals. Ethically challenged folk lurk in all walks of life, even among purported experts. Ox-goring and ax-grinding can be present in places where you least expect to find them.
Sorry I’m a bit confused. You were saying that Neogenesis has good product and now not anymore?
From our inception, our major goal has been to educate, so here goes. Rather than us answering in a binary “good vs. bad” constraint, we suggest you spend a few minutes reading posts on BFT that will provide information from which you can derive your own opinion. We have our own opinion, clearly disclosed in those posts. Let us know what you conclude.
What were they thinking? This makes no sense at all.
Scientific Misconduct in Medical Aesthetics Research (Part 1)
Scientific Misconduct in Medical Aesthetics Research (Part 2)
Hi. I’m wondering about your opinion on brand Neo Genesis
The links below take you to prior posts on BFT. We’ll let you draw your own conclusions about NeoGenesis after you read them.
What were they thinking? This makes no sense at all.
Scientific Misconduct in Medical Aesthetics Research (Part 1)
Scientific Misconduct in Medical Aesthetics Research (Part 2)